https://iphopen.org/index.php/se <p><strong>IPHO-Journal of Advance Research in Science And Engineering.<a href="https://portal.issn.org/resource/ISSN/3050-8797"><em>(e-ISSN.3050-8797, p-ISSN 3050-9270) </em></a></strong>Computer Science is the systematic study of the feasibility, structure, expression. It is one of the fastest growing career fields in modern history.Mechanical engineering is a discipline of engineering that applies the principles of engineering, physics and materials science for analysis, design,Electrical and electronics engineering is engineering branch, which focuses on the use of electricity on different forms. It is the branch which deals with the uses of biomechanics, aerodynamics, fluid mechanics, automobiles, hydraulics, infrastructure, designing, analysis of geotechnical studies</p> IPHO Journal en-US IPHO-Journal of Advance Research in Science And Engineering 3050-9270 <p>Author(s) and co-author(s) jointly and severally represent and warrant that the Article is original with the author(s) and does not infringe any copyright or violate any other right of any third parties and that the Article has not been published elsewhere. Author(s) agree to the terms that the <strong>IPHO Journal</strong> will have the full right to remove the published article on any misconduct found in the published article.</p> https://iphopen.org/index.php/se/article/view/285 <p style="font-weight: 400;"><em>Squamous cell carcinoma represents a widespread form of cancer that demands new innovative and effective therapeutic strategies to address its growth concern. This research investigates whether flaxseed oil functions as a supplemental therapeutic agent which improves the effectiveness of cisplatin against squamous cell carcinoma (SCC) cell lines particularly using the OECM-1 cell line. The experimental design involved quantifying SCC25 cell growth rates by investigating epidermal growth factor receptor activity in 96-well plates as the primary means to study biological process activity. The cell treatment consisted of studying flaxseed oil and cisplatin alone and combined to determine their cytotoxic effects. The IC50 values represent the concentration of the compound required to inhibit 50% of the epidermal growth factor receptors (EGFR) activity in SCC25 cells. The statistical tests involving one-way ANOVA and paired sample t-tests allowed measurement of cell viability at 24 and 48 hours after treatment. Results indicate that cells treated with flaxseed oil experienced a major decrease in cell viability from 46.28 to 29.14 (p = 0.007) and received similar reductions as cells treated with cisplatin which declined from 23.10 to 16.22 (p = 0.032). A remarkable change from 35.06 to 20.76 (p = 0.008) was observed through combined administration. Mean values within the control group dramatically increased to reflect the success of the treatments applied. This research establishes that therapeutic potential of flaxseed oil when paired with cisplatin treatment for squamous cell carcinoma. The research indicates that implementing natural compounds alongside conventional therapies leads to superior therapeutic outcomes and diminished side effects. Research initiatives should concentrate on detailed investigations of synergistic processes alongside clinical performance assessments for combined cancer treatments in medical settings. </em></p> Fatema Elturki Ghada Gehani Karima Alfitory Sumeia Werfalli Copyright (c) 2025 IPHO-Journal of Advance Research in Science And Engineering https://creativecommons.org/licenses/by-nc-sa/4.0 2025-03-27 2025-03-27 3 03 01 07 10.5281/zenodo.15094146